# Model-Agnostic AI Agent Tools

> Source: https://theagentsindex.com/collections/model-agnostic-ai-agent-tools (curated, quality-gated, re-verified)

A model-agnostic AI agent is one whose own listing names multiple model providers or an explicit bring-your-own-key (BYOK) layer, rather than baking in a single vendor's models. The set below is the buyers' shortlist when the question is "what runs everywhere": agents whose own product documentation names Claude, GPT, Gemini and at least one open-weight family, and where swapping the underlying model is a configuration change rather than a rewrite. Per-entry notes name which providers each agent explicitly supports, so the gap between "model-agnostic in name" and "model-agnostic in the listing's own text" is visible at a glance.

| Name | What it is | Why it's here | Pricing | API |
| --- | --- | --- | --- | --- |
| [Agno](https://theagentsindex.com/agno.md) | Python SDK, open-source AgentOS runtime and hosted control plane for building and operating agents. | One of 20+ providers reachable through its model-agnostic Python interface, alongside OpenAI, Ollama and others. | — | Yes |
| [Aider](https://theagentsindex.com/aider.md) | Open-source terminal AI pair programmer that edits files in your local git repo and commits the changes. | Anthropic is a named provider in its bring-your-own-key setup, alongside OpenAI, DeepSeek and local models. | — | Yes |
| [Botpress](https://theagentsindex.com/botpress.md) | AI agent platform with a visual studio, a code-first TypeScript ADK and a helpdesk, priced per conversation. | Anthropic Claude is one of the model-agnostic options, alongside OpenAI, Google Gemini and open-weight models. | — | Yes |
| [Cline](https://theagentsindex.com/cline.md) | Open-source coding agent for VS Code, JetBrains, the terminal and CI, running on whichever model you bring. | Anthropic is a named provider in its bring-your-own-key setup, alongside OpenAI or a local Ollama model. | — | Yes |
| [Dify](https://theagentsindex.com/dify.md) | Open-source platform for building agentic workflows, AI agents and RAG knowledge pipelines. | One of hundreds of model-agnostic options it can connect, alongside OpenAI, Google and open/local models. | — | Yes |
| [Google Agent Development Kit (ADK)](https://theagentsindex.com/google-adk.md) | Open-source framework for building, evaluating and deploying AI agents in Python, TypeScript, Go, Java or Kotlin. | Reachable via LiteLLM alongside 100+ other providers, on top of native first-party Gemini support. | — | Yes |
| [LangChain](https://theagentsindex.com/langchain.md) | Open source agent frameworks plus LangSmith, a hosted platform to trace, evaluate, deploy and govern agents. | The most widely-used multi-provider LLM framework, with integrations for Anthropic, OpenAI, Google, Mistral, Ollama and dozens more. | — | Yes |
| [LangGraph](https://theagentsindex.com/langgraph.md) | Open-source orchestration framework and runtime for stateful, long-running LLM agents, from LangChain. | Anthropic is a named provider in the standard model interface its agent runtime exposes, alongside OpenAI, Google and others. | — | Yes |
| [Letta](https://theagentsindex.com/letta.md) | Stateful agent harness, cloud and SDK for agents with persistent, git-versioned memory. | Free tier runs stateful agents with bring-your-own-keys for OpenAI, Anthropic, Google and any OpenAI-compatible local endpoint. | — | Yes |
| [LlamaIndex](https://theagentsindex.com/llamaindex.md) | Open-source agent framework plus a credit-metered document parsing, extraction and indexing platform. | Multi-provider LLM framework with Anthropic, OpenAI, Google, Mistral, DeepSeek, Ollama and Bedrock integrations wired through its agent stack. | — | Yes |
| [Microsoft Agent Framework](https://theagentsindex.com/microsoft-agent-framework.md) | Open-source .NET, Python and Go SDK for building AI agents and graph-based multi-agent workflows. | A named provider alongside Azure OpenAI, OpenAI, Ollama and Gemini (via its Go SDK). | — | Yes |
| [AutoGen](https://theagentsindex.com/microsoft-autogen.md) | Open-source Microsoft framework for building single and multi-agent AI applications in Python. | Free, MIT-licensed multi-agent framework where you pay only your chosen model provider: OpenAI, Azure OpenAI, Anthropic, Ollama and others. | — | Yes |
| [MindStudio](https://theagentsindex.com/mindstudio.md) | No-code platform for building, running and deploying AI agents as drag-and-drop workflows. | No-code visual builder for AI agents, with 200+ models from Anthropic, OpenAI, Google, Mistral, Meta and open-weight providers. | — | Yes |
| [n8n](https://theagentsindex.com/n8n.md) | Workflow automation platform for building and running AI agents on a visual canvas, with code where needed. | A named model-agnostic option alongside OpenAI and Ollama that its AI nodes can call. | — | Yes |
| [OpenAI Agents SDK (Python)](https://theagentsindex.com/openai-agents-sdk.md) | Open-source Python framework for building agents with tools, handoffs, guardrails and tracing. | Free and MIT-licensed framework: you pay only for the model API calls your agents make, to OpenAI or any other provider. | — | Yes |
| [OpenCode](https://theagentsindex.com/opencode.md) | Open source AI coding agent for the terminal, desktop app and IDE, with 75+ model providers. | Reachable through its 75+-provider Models.dev integration, alongside GPT, Gemini and local Ollama models. | — | Yes |
| [OpenHands](https://theagentsindex.com/openhands.md) | Open-source software engineering agent with GUI, CLI, SDK and an enterprise control plane. | One of the two providers its own text names by example (Claude or GPT) for a bring-your-own-key setup that's otherwise model-agnostic. | — | Yes |
| [Pydantic AI](https://theagentsindex.com/pydantic-ai.md) | Open-source Python agent framework from the Pydantic team, with a typed agent loop and swappable models. | A named provider in its type-safe, model-agnostic interface, alongside OpenAI, Gemini, Mistral and Ollama. | — | Yes |
| [Vapi](https://theagentsindex.com/vapi.md) | Developer platform for building, testing and deploying voice AI agents that make and receive phone calls. | A named provider (with OpenAI and Google) in its otherwise bring-your-own-model pipeline. | — | Yes |
| [Zed](https://theagentsindex.com/zed.md) | Rust-based code editor with a built-in agent panel, ACP external agents and Zed-hosted models. | First-class, named support alongside OpenAI, Google, Mistral, DeepSeek and more, and it natively runs Claude Code as an external agent via the ACP it created. | — | Yes |

## How this list is built

A tool earns a place here only when its own Published, sourced listing sets `attributes.modelAgnostic` to Yes, meaning the tool's own documentation names multiple model providers (Anthropic, OpenAI, Google, Mistral, Meta, DeepSeek and so on) or exposes an explicit bring-your-own-key layer where any compatible API endpoint can be plugged in. A single named provider with a roadmap promise of more does not qualify. Neither does a vendor's general "we work with all models" marketing claim that does not surface in the listing's own fields. Membership is derived from each listing's already-researched, quality-gated `attributes` and `integrations` data, not from inference about a tool's flexibility. Where a tool's claim to multi-provider support lives only in a third-party blog post or a community report, that is not enough; the listing must surface it in a field the listings lane has already verified.